{"artifact":{"id":"paper-fig-39995077-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 1: Formation of stress granules under physiological and pathophysiological conditio...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"pmid\": \"39995077\", \"relation\": \"extracted_from\"}]","content_hash":"0da8589182b6bb429b4754b9057c7201ed33cbfa27f839bcc4a1018325aedc65","metadata":{"doi":"10.4103/NRR.NRR-D-24-01196","pmid":"39995077","pmcid":"PMC12220703","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12220703/bin/NRR-21-588-g001.jpg","type":"external","tracked_at":"2026-04-10T20:51:31.352078"},"caption":"Formation of stress granules under physiological and pathophysiological conditions. mRNAs associate with RNA-binding proteins, including G3BP1 and G3BP2, to form ribonucleoprotein clusters, which are membrane-less organelles. These clusters phase separate and aggregate into molecular condensates called stress granules (SGs) that exhibit a dynamic liquid-like behavior. Under physiological conditions, SGs exchange molecules with their environment and maintain SG homeostasis. Under stress, these SGs assemble and inhibit translation, and this process is reversed when the stressor is removed. However, under pathological conditions such as neurodegeneration, cancer, and chronic stress, these clusters aggregate into gel- or solid-like SGs, resulting in dysregulated SG homeostasis.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12220703/bin/NRR-21-588-g001.jpg","image_path":"","description":"","figure_label":"Figure 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-10T13:51:31-07:00","updated_at":"2026-04-19T02:47:06.957796-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12220703/bin/NRR-21-588-g001.jpg","lifecycle_changed_at":"2026-04-10T13:51:31-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"cd4adba1-3e79-40eb-8f0c-5ad995017264","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-39995077","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 39995077"}],"incoming_links":[],"current_artifact_id":"paper-fig-39995077-1","is_canonical":true,"supersede_chain":["paper-fig-39995077-1"]}