{"artifact":{"id":"paper-fig-40102948-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 1: Dynamic expression of neutrophils and NETs after CLP over a period of time.  A  ...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"40102948\", \"relation\": \"extracted_from\"}]","content_hash":"66366959724e66199c90dd71c0d1d1440e41273db5cdda3d649c4b470d18324e","metadata":{"doi":"","pmcid":"PMC11917101","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig1_HTML.jpg","type":"external","tracked_at":"2026-04-16T11:31:44.154166"},"caption":"Dynamic expression of neutrophils and NETs after CLP over a period of time.  A  Schematic timeline of the experimental procedures.  B  and  C  Representative photographs of IF co-staining of Ly-6G and CD11b, a neutrophil biomarker, and quantification of the number of Ly-6G/CD11b + cell in the hippocampal CA1 region of mice from the sham group and CLP group at 4 h, 8 h, 12 h, 24 h, 48 h, 72 h, 5 days and 7 days (n = 6).  D  and  E  Representative photographs of IF staining of Cit-H3 with MPO, a NETs biomarker, and quantification of the number of Cit-H3/MPO/DAPI + cells in the hippocampal CA1 region of mice from the sham group and CLP group at 4 h, 8 h, 12 h, 24 h, 48 h, 72 h, 5 days and 7 days (n = 6). Nuclei were stained with DAPI. Scale bar = 20 µm. NETs: Neutrophil extracellular traps, CLP: Cecal Ligation and Puncture; Cit-H3: Citrullinated histones H3; MPO: Myeloperoxidase; IF: immunofluorescence. (Data are expressed as the mean ± SD. * p  < 0.05 compared with sham, ns: no significa","paper_id":"40102948","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig1_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-16T11:31:44-07:00","updated_at":"2026-04-16T20:55:17.546747-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig1_HTML.jpg","lifecycle_changed_at":"2026-04-16T11:31:44-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e2004151-7787-4df1-b891-95f50eeeea78","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-40102948","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 40102948"}],"incoming_links":[],"current_artifact_id":"paper-fig-40102948-1","is_canonical":true,"supersede_chain":["paper-fig-40102948-1"]}