{"artifact":{"id":"paper-fig-40102948-10","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 10: The LF3 treatment reversed the expression of Wnt3/β-catenin/TCF4 signaling pathw...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"40102948\", \"relation\": \"extracted_from\"}]","content_hash":"f1e61eacfdb21b4ed3b117e74e2469e8b3cdcd5c3c7bc1b4a580669c6e10267c","metadata":{"doi":"","pmcid":"PMC11917101","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig10_HTML.jpg","type":"external","tracked_at":"2026-04-16T11:31:44.348737"},"caption":"The LF3 treatment reversed the expression of Wnt3/β-catenin/TCF4 signaling pathway, TJs and AJs proteins.  A  Western blot detected the Wnt/β-catenin/TCF4 signaling proteins expression levels in the hippocampus after LF3 treatment (n = 6).  B – F  The quantification analysis of Wnt/β-catenin/TCF4 signaling proteins expression levels after LF3 treatment (n = 6).  G  Western blot detected the TJs and AJs proteins expression levels in the hippocampus after LF3 treatment (n = 6).  H – M  The quantification analysis of TJs and AJs proteins expression levels after LF3 treatment (n = 6). NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; BBB: Blood–brain barrier; TJs: Tight junctions; AJs: adherens junction (ns: no significance, * p  < 0.05, ** p  < 0.01, *** p  < 0.001, **** p  < 0.0001)","paper_id":"40102948","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig10_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 10","figure_number":10,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-16T11:31:44-07:00","updated_at":"2026-04-16T20:55:17.546747-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig10_HTML.jpg","lifecycle_changed_at":"2026-04-16T11:31:44-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"36324369-d576-4589-864a-f416b2a85315","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-40102948","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 40102948"}],"incoming_links":[],"current_artifact_id":"paper-fig-40102948-10","is_canonical":true,"supersede_chain":["paper-fig-40102948-10"]}