{"artifact":{"id":"paper-fig-40102948-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 2: The inhibition of NETs formation improved SAE mice survival, defended neuroinfla...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"40102948\", \"relation\": \"extracted_from\"}]","content_hash":"f59cb6a4cf89a9c8de702f9275c83ffefa750043a017692b952a2cbdb911f0d3","metadata":{"doi":"","pmcid":"PMC11917101","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig2_HTML.jpg","type":"external","tracked_at":"2026-04-16T11:31:44.176112"},"caption":"The inhibition of NETs formation improved SAE mice survival, defended neuroinflammation and alleviated cognitive impairment.  A  7-day survival rates of SAE mice treated with different concentrations of GSK484 (n = 15).  B  Quantification of NETs numbers (n = 6).  C  and  D  GSK484 inhibited NETs formation in the CA1 region of the hippocampus by IF staining (n = 6).  E – H  ELISA test showed that GSK484 decreased the levels of TNF-α, IL-6, IL-1β and IL-10 in hippocampus tissue (n = 6).  I  The trace heat map of OFT. The time ( J ) and the movement distance ( K ) in center in OFT.  L  The trace heat map of MWM test. The movement distance ( M ) in island, and the time ( N ) in NW area in the MWM test were increased after GSK484 treatment (n = 6). NETs: Neutrophil extracellular traps; CLP: Cecal Ligation and Puncture; SAE: Sepsis-associated encephalopathy; IF: immunofluorescence; OFT: open field test; MWM: Morris water maze. (ns: no significance, * p  < 0.05, ** p  < 0.01, *** p  < 0.001,","paper_id":"40102948","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig2_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-16T11:31:44-07:00","updated_at":"2026-04-16T20:55:17.546747-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig2_HTML.jpg","lifecycle_changed_at":"2026-04-16T11:31:44-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"9f63e62e-13d9-4853-9772-b15beeb7c733","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-40102948","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 40102948"}],"incoming_links":[],"current_artifact_id":"paper-fig-40102948-2","is_canonical":true,"supersede_chain":["paper-fig-40102948-2"]}