{"artifact":{"id":"paper-fig-40102948-3","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 3: Distinct transcriptional signature between CLP- and GSK484-treated hippocampus. ...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"40102948\", \"relation\": \"extracted_from\"}]","content_hash":"ba5092d39abb2b3e28ccf4be0b672e0aed098deaf3254d5b300eb7e80bbf2f25","metadata":{"doi":"","pmcid":"PMC11917101","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig3_HTML.jpg","type":"external","tracked_at":"2026-04-16T11:31:44.197085"},"caption":"Distinct transcriptional signature between CLP- and GSK484-treated hippocampus.  A  A vulcano plot was depicted with  p  < 0.05 of all 705 detected genes from RNA-Seq dataset. Differential expression genes (DEGs) were colored with blue and red, regarding to 163 down-regulated and 542 up-regulated genes, respectively.  B  Bar plot of GO enrichment analysis; (BP) biological process, (CC) cellular components, (MF) molecular function.  C  Bubble plot of KEGG pathway analysis.  D  Cytoscape was used to visualize the PPI network generated by String.  E  The top 10 hub genes were obtained using the CytoHubba plug-in in Cytoscape.  F  The top 1 modules are presented based on MCODE scores in descending order. DEGs: Differential expression genes; BP: biological process; CC: cellular components; MF: molecular function; CLP: Cecal Ligation and Puncture; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes","paper_id":"40102948","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig3_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-16T11:31:44-07:00","updated_at":"2026-04-16T20:55:17.546747-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11917101/bin/12974_2025_3395_Fig3_HTML.jpg","lifecycle_changed_at":"2026-04-16T11:31:44-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4906ec56-4875-4676-b953-042693441624","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-40102948","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 40102948"}],"incoming_links":[],"current_artifact_id":"paper-fig-40102948-3","is_canonical":true,"supersede_chain":["paper-fig-40102948-3"]}