{"artifact":{"id":"paper-fig-41279937-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 1.: Alpha-synuclein proteoforms in the appendix and substantia nigra (SN) (A)  Bar p...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"41279937\", \"relation\": \"extracted_from\"}]","content_hash":"421849a312e3fae2fa7e267d815c835b7f0ec6be808fd20777e7e30ef08f435a","metadata":{"doi":"","pmcid":"PMC12632551","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12632551/bin/nihpp-2025.10.07.680938v1-f0001.jpg","type":"external","tracked_at":"2026-04-28T07:22:23.393405"},"caption":"Alpha-synuclein proteoforms in the appendix and substantia nigra (SN) (A)  Bar plot showing 65 alpha-synuclein proteoforms identified in the human appendix and SN. Acetylated proteoforms are colored dark blue; unacetylated proteoforms are colored light blue. Nine proteoforms, which were only found in the appendix, are denoted with *.  (B)  Bar plot showing alpha-synuclein proteoforms distribution according to their abundance in the human appendix and SN separately. X-axis shows the percentage of the abundance for each existing proteoform. Top 5 most abundant proteoforms are listed with their color codes.  (C)  Common alpha-synuclein and rare proteoforms showing tissue differences. For common alpha-synuclein proteoforms, robust linear regression was used for statistical analysis adjusting for diagnosis (synucleinopathy/control) and age, with proteoform abundance as dependent variable (Y) and tissue as independent variable (X). Proteoforms showing significant tissue differences after FDR","paper_id":"41279937","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12632551/bin/nihpp-2025.10.07.680938v1-f0001.jpg","image_path":"","description":"","figure_label":"Figure 1.","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-28T00:22:23.393493-07:00","updated_at":"2026-04-28T00:22:23.393493-07:00","version_number":5,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12632551/bin/nihpp-2025.10.07.680938v1-f0001.jpg","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"63f9a737-d796-4677-b7a2-168a9f5386fc","artifact_dir":"data/scidex-artifacts/63/63f9a737-d796-4677-b7a2-168a9f5386fc","primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":"2026-04-28T23:09:20.979819-07:00","hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-41279937-1","is_canonical":true,"supersede_chain":["paper-fig-41279937-1"]}