{"artifact":{"id":"paper-fig-41569436-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 1: Dynamic microglial activation programs and signaling networks in Alzheimer’s dis...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"pmid\": \"41569436\", \"relation\": \"extracted_from\"}]","content_hash":"c8e666a0dde4cf117bfdfc92fd9ff9e0ec4c267d80f693ddc2eebeda950a73f1","metadata":{"doi":"10.1007/s10571-026-01671-4","pmid":"41569436","pmcid":"PMC12891327","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig1_HTML.jpg","type":"external","tracked_at":"2026-04-11T18:42:25.464335"},"caption":"Dynamic microglial activation programs and signaling networks in Alzheimer’s disease (AD). Under physiological conditions, microglia exist in a state of homeostatic surveillance, which is essential for maintaining synapses and monitoring the immune system. In response to amyloid-β accumulation, tau pathology, and cellular stress, microglia undergo dynamic transcriptional and functional reprogramming rather than fixed polarization. Pro-inflammatory microglial activation programs, driven by Toll-like receptors (TLR), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and Janus kinase (JAK)-signal transducer and activator of transcription (STAT) (JAK/STAT) signaling, promote cytokine release, oxidative stress, and neuronal injury when persistently engaged. Conversely, repair-associated and phagocytic microglial programs regulated by AMP-activated protein kinase (AMPK), phosphoinositide 3-kinase/ protein kinase B (PI3K/AKT), peroxisome proliferator-activated receptor g","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig1_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-11T11:42:25-07:00","updated_at":"2026-04-18T21:54:00.100607-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig1_HTML.jpg","lifecycle_changed_at":"2026-04-11T11:42:25-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"ef1d24f7-545d-46c8-a4be-8feeab563701","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41569436","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 41569436"}],"incoming_links":[],"current_artifact_id":"paper-fig-41569436-1","is_canonical":true,"supersede_chain":["paper-fig-41569436-1"]}