{"artifact":{"id":"paper-fig-41569436-5","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 5: Molecular mechanism of NLRP3 inflammasome activation in Alzheimer’s disease (AD)...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"pmid\": \"41569436\", \"relation\": \"extracted_from\"}]","content_hash":"b21278617b07422d2e054ddc3eb39d44212d94e44c927606afde06f45263a427","metadata":{"doi":"","pmid":"41569436","pmcid":"PMC12891327","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig5_HTML.jpg","type":"external","tracked_at":"2026-04-11T18:50:11.782942"},"caption":"Molecular mechanism of NLRP3 inflammasome activation in Alzheimer’s disease (AD). The schematic depicts the two-step activation process: (1) Priming (Signal 1) via TLR/NF-κB signaling upregulates NLRP3 and pro-IL-1β; (2) Activation (Signal 2) occurs upon exposure to Aβ oligomers, ATP, ROS, lysosomal rupture, or mitochondrial dysfunction, leading to NLRP3 oligomerization, ASC speck formation, and caspase-1 activation. Active caspase-1 cleaves pro-IL-1β and pro-IL-18 into mature cytokines and processes gasdermin D (GSDMD) to form membrane pores, inducing pyroptosis. The downstream effects include glial activation, impaired Aβ clearance, tau hyperphosphorylation, and neuronal death, forming a self-amplifying neuroinflammatory loop central to AD pathogenesis","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig5_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 5","figure_number":5,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-11T11:50:11-07:00","updated_at":"2026-04-18T21:54:00.100607-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig5_HTML.jpg","lifecycle_changed_at":"2026-04-11T11:50:11-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"0e296ebe-eca1-4461-9e68-9cea3e8ef2ab","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41569436","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 41569436"}],"incoming_links":[],"current_artifact_id":"paper-fig-41569436-5","is_canonical":true,"supersede_chain":["paper-fig-41569436-5"]}