{"artifact":{"id":"paper-fig-41569436-6","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 6: Peripheral immune cell trafficking and interactions in Alzheimer’s disease (AD)....","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"pmid\": \"41569436\", \"relation\": \"extracted_from\"}]","content_hash":"a8dac315063e184a9b5157994931c913ab2d44ab94cf448c05b1c11c09b96561","metadata":{"doi":"","pmid":"41569436","pmcid":"PMC12891327","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig6_HTML.jpg","type":"external","tracked_at":"2026-04-11T18:50:11.798802"},"caption":"Peripheral immune cell trafficking and interactions in Alzheimer’s disease (AD). In AD, blood-brain barrier (BBB) disruption, accompanied by increased vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule 1 (ICAM-1) expression, facilitates immune infiltration. Major cell types include: (1) monocytes/macrophages with impaired phagocytosis and dysregulated pro-inflammatory/repair-associated microglia polarization; (2) dendritic cells engaged in amyloid-β (Aβ) clearance and antigen presentation; (3) T cells, pro-inflammatory Th1/Th17, regulatory Tregs, and cytotoxic CD8+; (4) B cells producing Aβ-targeting antibodies and inflammatory cytokines; (5) natural killer (NK) cells with heightened interferon-γ (IFN-γ) and tumor necrosis factor alpha (TNF-α) release; and (6) neutrophils releasing reactive oxygen species (ROS), proteases, and forming neutrophil extracellular traps (NETs). Lymphatic drainage to cervical nodes and chemokine gradients, i.e., C-C motif chemokin","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig6_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 6","figure_number":6,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-11T11:50:11-07:00","updated_at":"2026-04-18T21:54:00.100607-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12891327/bin/10571_2026_1671_Fig6_HTML.jpg","lifecycle_changed_at":"2026-04-11T11:50:11-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"599eac14-faa8-487c-912e-e226db3ee4ba","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41569436","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 41569436"}],"incoming_links":[],"current_artifact_id":"paper-fig-41569436-6","is_canonical":true,"supersede_chain":["paper-fig-41569436-6"]}