{"artifact":{"id":"paper-fig-41900026-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 1: The vicious cycle of TDP-43-mediated proteostatic collapse. TDP-43 aggregates ac...","quality_score":0.95,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"pmid\": \"41900026\", \"relation\": \"extracted_from\"}]","content_hash":"e1022d281014cfd8a1852f7a0a4d870bc4877d2e74b93f0780fbbe19d6a828f4","metadata":{"doi":"10.3390/molecules31060924","pmid":"41900026","pmcid":"PMC13028736","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC13028736/bin/molecules-31-00924-g001.jpg","type":"external","tracked_at":"2026-04-11T18:51:04.268953"},"caption":"The vicious cycle of TDP-43-mediated proteostatic collapse. TDP-43 aggregates actively contribute to pathology rather than merely serving as passive metabolic waste. They sequester essential components of the UPS, such as ubiquitin and E2/E3 ligases, and disrupt the ALP by depleting related components (e.g., dynactin-1), which are essential for autophagosome-lysosomal fusion. This leads to a self-perpetuating “vicious cycle” in which TDP-43 disrupts the very complexes responsible for its clearance, thereby impairing autophagic flux. Created in BioRender. Angelo Jamerlan. (2025)  https://BioRender.com/ .","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13028736/bin/molecules-31-00924-g001.jpg","image_path":"","description":"","figure_label":"Figure 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-11T11:51:04-07:00","updated_at":"2026-04-18T21:54:00.100607-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13028736/bin/molecules-31-00924-g001.jpg","lifecycle_changed_at":"2026-04-11T11:51:04-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"f0f4ad6d-4c46-4243-b445-04bf1bb25833","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41900026","link_type":"derives_from","strength":1.0,"evidence":"paper_figure metadata/provenance references PMID 41900026"}],"incoming_links":[],"current_artifact_id":"paper-fig-41900026-1","is_canonical":true,"supersede_chain":["paper-fig-41900026-1"]}