{"artifact":{"id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Extended Data Fig. 1: CONSORT diagram and zygosity status. a , CONSORT diagram outlining inclusion cri...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"51fd0021-0cc8-4669-b21b-53650ed26d0f\", \"relation\": \"extracted_from\"}]","content_hash":"0dcfde838c10a866b37321c6eae80ac03563323bdcf2e32cfe341082c78279c7","metadata":{"doi":"10.1038/s41586-026-10197-0","pmcid":"PMC13083263","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig5_ESM.jpg","type":"external","tracked_at":"2026-04-27T11:55:49.455660"},"caption":"CONSORT diagram and zygosity status. a , CONSORT diagram outlining inclusion criteria for germline–somatic analysis and CDK4/6i outcome analysis comparing g BRCA2  to g WT . Cases were excluded from further clinicogenomic analysis if clinical or pathological data were not available, if the patient did not have invasive breast cancer (i.e. ductal carcinoma in situ was sequenced), and if the patient had multiple evolutionarily distinct tumors with discordant receptor status (n = 315 excluded total). Patients were excluded if zygosity could not be ascertained due to technical reasons (including indeterminate LOH in the genes of interest); patients with loss of mutated allele were also excluded from analysis. Patients were excluded from downstream analysis of CDK4/6i + ET and endocrine therapy outcomes for the following reasons if: i) initial receptor status was TNBC or HER2 + , ii) the patients received CDK4/6i for <2 weeks prior to toxicity, iii) if all the known sites of disease were ab","paper_id":"51fd0021-0cc8-4669-b21b-53650ed26d0f","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig5_ESM.jpg","image_path":"","description":"","figure_label":"Extended Data Fig. 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-27T04:55:49.455796-07:00","updated_at":"2026-04-27T04:55:49.455796-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig5_ESM.jpg","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"2ab7acd6-9d32-41e8-9d75-17fc4aaf4ba7","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-1","is_canonical":true,"supersede_chain":["paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-1"]}