{"artifact":{"id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-12","artifact_type":"paper_figure","entity_ids":"[]","title":"Extended Data Fig. 9: Implications of HRD signature on CDK4/6i PFS in g BRCA2  WT breast cancers. HRD ...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"51fd0021-0cc8-4669-b21b-53650ed26d0f\", \"relation\": \"extracted_from\"}]","content_hash":"73662c5601a7d050e433eb31375cf98ec97aa7828287876f0d97ded37c93488d","metadata":{"doi":"10.1038/s41586-026-10197-0","pmcid":"PMC13083263","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig13_ESM.jpg","type":"external","tracked_at":"2026-04-27T11:55:50.170495"},"caption":"Implications of HRD signature on CDK4/6i PFS in g BRCA2  WT breast cancers. HRD inference was performed with an orthogonal method (HRD-IMPACT, see  Methods ). This included calculation of large state transitions (LST), telomeric allelic imbalance (TAI) and LOH from samples that passed purity and ASCN imputation QC metrics. The HR was derived using a Cox proportional hazard model ( P  from two-sided Wald test). Among g BRCA2  WT patients, HRD was associated with a significantly shorter PFS (HR = 1.78, 95% CI: 1.27 – 2.48,  P  = 0.00075).","paper_id":"51fd0021-0cc8-4669-b21b-53650ed26d0f","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig13_ESM.jpg","image_path":"","description":"","figure_label":"Extended Data Fig. 9","figure_number":12,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-27T04:55:50.170629-07:00","updated_at":"2026-04-27T04:55:50.170629-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig13_ESM.jpg","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5f5d1635-9eb8-46e2-84a7-8a6624a523e3","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-12","is_canonical":true,"supersede_chain":["paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-12"]}