{"artifact":{"id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 1: Germline–somatic interactions in breast cancer. a , Study schema. Enrichment ana...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"51fd0021-0cc8-4669-b21b-53650ed26d0f\", \"relation\": \"extracted_from\"}]","content_hash":"70b42efab77b80529f2e6eadaf5fe4801b9ba3bccf466bbdb50507667e92f8f1","metadata":{"doi":"10.1038/s41586-026-10197-0","pmcid":"PMC13083263","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig1_HTML.jpg","type":"external","tracked_at":"2026-04-27T11:55:49.523140"},"caption":"Germline–somatic interactions in breast cancer. a , Study schema. Enrichment analysis was performed to identify somatic alterations more prevalent in patients with pathogenic germline variants of homologous recombination pathway genes (compared with ‘sporadic’ or gWT cases). FC, fold change; LCN, lesser copy number; TCN, total copy number. Schematic created in BioRender; Razavi, P.  https://biorender.com/hv0bvbr  (2025).  b , Enrichment analysis of g ATM  ( n  = 60) compared with gWT ( n  = 5,094), as determined by Firth-penalized logistic regression with sample type and receptor status as covariates. Significant genes (blue) are defined by  q  < 0.10.  c , As in panel  b , but for comparison of g BRCA1  ( n  = 142) with gWT ( n  = 5,904).g BRCA1  tumours were enriched for somatic  TP53  variants; OR = 2.80 (95% CI 1.70–4.59,  q  = 0.0009) and mutually exclusive with  PIK3CA  variants.  d , As in panels  b , c , but for comparison of g BRCA2  ( n  = 161) compared with gWT ( n  = 5,094)","paper_id":"51fd0021-0cc8-4669-b21b-53650ed26d0f","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig1_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 1","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-27T04:55:49.523296-07:00","updated_at":"2026-04-27T04:55:49.523296-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig1_HTML.jpg","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"c7c95266-182b-4510-91de-8d9366484a45","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-2","is_canonical":true,"supersede_chain":["paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-2"]}