{"artifact":{"id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-8","artifact_type":"paper_figure","entity_ids":"[]","title":"Extended Data Fig. 5: Validation of concurrent  RB1  and  BRCA2  LOH in external g BRCA2  WES cohort. ...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"51fd0021-0cc8-4669-b21b-53650ed26d0f\", \"relation\": \"extracted_from\"}]","content_hash":"672d20d1fef93e179235dea9381fccc5b0b88c37995a0c483f5fc4213f554d94","metadata":{"doi":"10.1038/s41586-026-10197-0","pmcid":"PMC13083263","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig9_ESM.jpg","type":"external","tracked_at":"2026-04-27T11:55:49.923308"},"caption":"Validation of concurrent  RB1  and  BRCA2  LOH in external g BRCA2  WES cohort. FACETS was performed on whole-exome sequencing of g BRCA2  breast cancer samples from Abramson Cancer Center at the University of Pennsylvania (n = 24), and the Mayo Clinic (n = 22). Of these samples, 38 (82.6%) demonstrated concurrent LOH of  BRCA2  and  RB1 . The association between  RB1  LOH and  BRCA2  LOH was statistically significant by two-sided Fisher’s exact test (OR = Inf, 95% CI: 11.12 – Inf,  P  < 0.00001).","paper_id":"51fd0021-0cc8-4669-b21b-53650ed26d0f","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig9_ESM.jpg","image_path":"","description":"","figure_label":"Extended Data Fig. 5","figure_number":8,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-27T04:55:49.923437-07:00","updated_at":"2026-04-27T04:55:49.923437-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13083263/bin/41586_2026_10197_Fig9_ESM.jpg","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"befd79b4-ccfd-42dd-9d49-f71e30260fb1","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-8","is_canonical":true,"supersede_chain":["paper-fig-51fd0021-0cc8-4669-b21b-53650ed26d0f-8"]}