{"artifact":{"id":"paper-fig-55098313-7105-44ac-8daf-b540f61c267e-3","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 3 — Relationship between cerebral small vessel disease and proteinopathies in the me","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"55098313-7105-44ac-8daf-b540f61c267e\", \"timestamp\": \"2026-04-22T01:29:40.900774\"}]","content_hash":null,"metadata":{"pmid":"55098313-7105-44ac-8daf-b540f61c267e","caption":"Association between cerebral amyloid angiopathy (CAA) and proteinopathies. The plots visualize the association between CAA and Aβ-plaques, tau-tangles, and pTDP-43 in linear mixed effects models, that included CAA percentage area, age at death, and sex as fixed-factors and Braak-stage group, case, and region of interest as random-factors. CAA percentage area was positively associated with both Aβ plaques percentage area ( A ) and with density of tau-tangles ( B ). There was no significant association between CAA and density of phosphorylated-TAR-DNA-binding protein 43 (pTDP-43) cytoplasmatic inclusions ( C ). The models explained a large part of the variance of the dependent variable. Key: AM = amygdala; RC = rhinal cortex; Est. = estimate; HC = hippocampal body; PHC = posterior parahippocampal cortex","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12265290/bin/40478_2025_2076_Fig3_HTML.jpg","paper_title":"Relationship between cerebral small vessel disease and proteinopathies in the medial temporal lobe.","figure_label":"Fig. 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d99148aa-29d3-4697-bc65-489cc898a7c0","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-55098313-7105-44ac-8daf-b540f61c267e-3","is_canonical":true,"supersede_chain":["paper-fig-55098313-7105-44ac-8daf-b540f61c267e-3"]}