{"artifact":{"id":"paper-fig-55fef41e-e603-42c9-82c0-6c39dc5c574d-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 1: Pathophysiological mechanisms of ferroptosis in diabetes and its complications. ...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"55fef41e-e603-42c9-82c0-6c39dc5c574d\", \"relation\": \"extracted_from\"}]","content_hash":"55e93b3823f95a6e8624a8a2de3917649e4630c3e4a2d364cd7ec8178b50812c","metadata":{"doi":"10.3390/antiox15030369","pmcid":"PMC13023684","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC13023684/bin/antioxidants-15-00369-g001.jpg","type":"external","tracked_at":"2026-04-27T06:18:48.866477"},"caption":"Pathophysiological mechanisms of ferroptosis in diabetes and its complications. Diabetes-associated metabolic disturbances, including hyperglycemia, hyperlipidemia, and chronic inflammation, lead to excessive production of reactive oxygen species, inducing oxidative stress. In addition, diabetic metabolic disturbances increase the labile iron pool and ACSL4 levels, and impair the xCT/GSH/GPX4 axis, resulting in increased lipid peroxidation and ultimately ferroptosis. Ferroptosis contributes to pancreatic β-cell death and plays a pivotal role in the development and progression of diabetic complications, including nephropathy, cardiomyopathy, retinopathy, and dysfunction of the liver, brain, bones, skin, and male reproductive system. Created in BioRender. Vidakovic, M. (2026)  https://BioRender.com/2oq0pif  (accessed on 29 December 2025).","paper_id":"55fef41e-e603-42c9-82c0-6c39dc5c574d","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13023684/bin/antioxidants-15-00369-g001.jpg","image_path":"","description":"","figure_label":"Figure 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-26T23:18:48.866589-07:00","updated_at":"2026-04-26T23:18:48.866589-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13023684/bin/antioxidants-15-00369-g001.jpg","lifecycle_changed_at":"2026-04-26T23:18:48.866589-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"86f80cef-23fc-4efc-b508-087cf70de84d","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-55fef41e-e603-42c9-82c0-6c39dc5c574d-1","is_canonical":true,"supersede_chain":["paper-fig-55fef41e-e603-42c9-82c0-6c39dc5c574d-1"]}