{"artifact":{"id":"paper-fig-628fa8a9-ae8b-46d8-8a55-06b83c31644d-9","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 9: APOE and APOD regulated by estrogen modulated the migration of endometrial cance...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"628fa8a9-ae8b-46d8-8a55-06b83c31644d\", \"relation\": \"extracted_from\"}]","content_hash":"c844afcfa2e0276bf85d5ddd71c6ca8ee39bb44cf50ca9b381e4b44b3d9acd85","metadata":{"doi":"10.3389/fimmu.2026.1646920","pmcid":"PMC12950738","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12950738/bin/fimmu-17-1646920-g009.jpg","type":"external","tracked_at":"2026-04-27T11:55:52.954330"},"caption":"APOE and APOD regulated by estrogen modulated the migration of endometrial cancer cell.  (A)  Western blotting analysis of APOD and APOE in ISHKAWA cells treated with control (DMSO, solvent of E2) or 10 -8 mol/L E2 for 48 hours;  (B)  Wound healing assay was performed to assess cell migration. Cells were transfected with control (DMSO), si-APOD RNA and si-APOE RNA. Migratory cells were observed using an IX711 phase contrast microscope (Olympus Corporation) at 0 and 48 h (magnification, ×200). E2: 17β-estradiol; si-APOD RNA: lentivirus of siRNA targeting APOD; si-APOE RNA: lentivirus of siRNA targeting APOE. ns : no significance;  ** p  < 0.05.","paper_id":"628fa8a9-ae8b-46d8-8a55-06b83c31644d","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12950738/bin/fimmu-17-1646920-g009.jpg","image_path":"","description":"","figure_label":"Figure 9","figure_number":9,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-27T04:55:52.954449-07:00","updated_at":"2026-04-27T04:55:52.954449-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12950738/bin/fimmu-17-1646920-g009.jpg","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"a787f71f-5738-4f94-b280-063697d846e9","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-628fa8a9-ae8b-46d8-8a55-06b83c31644d-9","is_canonical":true,"supersede_chain":["paper-fig-628fa8a9-ae8b-46d8-8a55-06b83c31644d-9"]}