{"artifact":{"id":"paper-fig-6512908d-5fae-41e7-acab-de26b310cea2-3","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 3: GSEA of custom mitochondrial and immune pathways in osteocytes, hBMSCs, and brai...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"6512908d-5fae-41e7-acab-de26b310cea2\", \"relation\": \"extracted_from\"}]","content_hash":"6e8187e72c82189255efefaacff2e452bea22cfcf2e3b1ce90085b9201945296","metadata":{"doi":"10.1186/s12967-025-07505-z","pmcid":"PMC12829014","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12829014/bin/12967_2025_7505_Fig3_HTML.jpg","type":"external","tracked_at":"2026-04-22T22:50:11.397969"},"caption":"GSEA of custom mitochondrial and immune pathways in osteocytes, hBMSCs, and brain under spaceflight. (“GSEA-Cust Infl_MITO”): this is a GSEA custom pathway analysis according to [ 94 ]. Normalized enrichment scores (NES) for mitochondrial- and immune-related modules (rows) are plotted as lollipops for osteocytes (2, 4, 6 days; mouse), hBMSCs (14 days; human), and brain (84 days; mouse) comparing spaceflight to ground controls. A positive NES indicates pathway activation (red), and a negative NES indicates inhibition (blue). Circle size is inversely proportional to the false discovery rate (FDR); only results with FDR < 0.3 are shown. Pathways were defined in collaboration with D. Wallace [ 94 ], and include modules for antigen presentation, innate immunity, PANoptosis (apoptosis, necroptosis, inflammasome), oxidative phosphorylation (OXPHOS) complexes I–V and mitochondrial ribosome, mtDna/dsrna immune sensing and vesicle release, integrated stress response (ISR), unfolded protein respo","paper_id":"6512908d-5fae-41e7-acab-de26b310cea2","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12829014/bin/12967_2025_7505_Fig3_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-22T15:50:11.398093-07:00","updated_at":"2026-04-22T15:50:11.398093-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12829014/bin/12967_2025_7505_Fig3_HTML.jpg","lifecycle_changed_at":"2026-04-22T15:50:11.398093-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e6a5d6c8-6617-49b2-bcba-9c06bce3897c","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-6512908d-5fae-41e7-acab-de26b310cea2-3","is_canonical":true,"supersede_chain":["paper-fig-6512908d-5fae-41e7-acab-de26b310cea2-3"]}