{"artifact":{"id":"paper-fig-707e4dfb-3896-4244-8e2a-7a749d45b168-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 1: Up-regulation of ZFP64 in DOX-resistant TNBC tissues was positively associated w...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"707e4dfb-3896-4244-8e2a-7a749d45b168\", \"relation\": \"extracted_from\"}]","content_hash":"18a90152b9f79de1e031aa2c897479045ccdb9ee7266b749e721b8f5007861e9","metadata":{"doi":"10.1186/s12967-025-06246-3","pmcid":"PMC11871786","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig1_HTML.jpg","type":"external","tracked_at":"2026-04-23T01:08:29.029386"},"caption":"Up-regulation of ZFP64 in DOX-resistant TNBC tissues was positively associated with high histone lactylation level. ( A & B ) Pan-Kla level in DOX-resistant/sensitive TNBC tissues was evaluated by immunofluorescence staining. ( C ) The protein levels of pan-Kla and H3K18la in DOX-resistant/sensitive TNBC tissues were assessed by Western blotting. ( D ) RT-qPCR analysis of ZFP64 mRNA expression in DOX-resistant/sensitive TNBC tissues. ( E ) Pearson correlation test analyzed the correlation between ZFP64 and lactylation levels. ( F ) Western blotting determined ZFP64 protein abundance in DOX-resistant/sensitive TNBC tissues. ( G ) Co-localization of ZFP64 and H3K18la in DOX-resistant/sensitive TNBC tissues was observed by immunofluorescence staining. Student’s t test was performed for statistical analysis. * p  < 0.05, ** p  < 0.01, *** p  < 0.001","paper_id":"707e4dfb-3896-4244-8e2a-7a749d45b168","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig1_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-22T18:08:29.029463-07:00","updated_at":"2026-04-22T18:08:29.029463-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig1_HTML.jpg","lifecycle_changed_at":"2026-04-22T18:08:29.029463-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"9b504226-7045-42c5-a6a9-02875a2577ca","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-707e4dfb-3896-4244-8e2a-7a749d45b168-1","is_canonical":true,"supersede_chain":["paper-fig-707e4dfb-3896-4244-8e2a-7a749d45b168-1"]}