{"artifact":{"id":"paper-fig-93c82e61-7b82-459b-a0fb-fc0b08049018-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 1: Schematic diagram of nutritional medicine targeting Nrf2 signaling pathway to in...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"93c82e61-7b82-459b-a0fb-fc0b08049018\", \"relation\": \"extracted_from\"}]","content_hash":"f238e54282056217dcf697827036f48fc566437e64c43637534958fe761a6567","metadata":{"doi":"10.3390/nu18040600","pmcid":"PMC12943260","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12943260/bin/nutrients-18-00600-g001.jpg","type":"external","tracked_at":"2026-04-27T11:56:00.229306"},"caption":"Schematic diagram of nutritional medicine targeting Nrf2 signaling pathway to inhibit microplastic-induced NLRP3 inflammasome activation and pyroptosis in diabetes and related complications. ROS—reactive oxygen species; Nrf2—nuclear factor erythroid 2-related factor 2; NF-κB—nuclear factor kappa-light-chain enhancer of activated B cells; HO-1—heme oxygenase-1; SOD—superoxide dismutase; CAT—catalase; NLRP3—NLR family pyrin domain containing 3; GSDMD—gasdermin D; TXNIP—thioredoxin-interacting protein; IL-18—interleukin-18; TNF-α—tumor necrosis factor alpha; IL-1β—interleukin-1 beta; ASC—apoptosis-associated speck-like protein containing a CARD; GSDMD-NT—gasdermin D  N -terminal; IRS1—insulin receptor substrate 1; IRS2—insulin receptor substrate 2; MAPK—mitogen-activated protein kinase; ERK—extracellular signal-regulated kinase; PI3K—phosphoinositide 3-kinase; Akt—protein kinase B; GSK3β—glycogen synthase kinase-3 beta.","paper_id":"93c82e61-7b82-459b-a0fb-fc0b08049018","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12943260/bin/nutrients-18-00600-g001.jpg","image_path":"","description":"","figure_label":"Figure 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-27T04:56:00.229448-07:00","updated_at":"2026-04-27T04:56:00.229448-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12943260/bin/nutrients-18-00600-g001.jpg","lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e6896cfa-d913-41a0-91ae-ec987d113763","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-93c82e61-7b82-459b-a0fb-fc0b08049018-1","is_canonical":true,"supersede_chain":["paper-fig-93c82e61-7b82-459b-a0fb-fc0b08049018-1"]}