{"artifact":{"id":"paper-fig-9a10f9ee-2201-47b2-a4ca-b169666a53d9-8","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 7: Cardiac-specific PDE4D-knockdown activates mitophagy and protects against TAC-in...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"9a10f9ee-2201-47b2-a4ca-b169666a53d9\", \"relation\": \"extracted_from\"}]","content_hash":"429d46b87396e252e61da3ce5f1306b88cae2f90ea2f5a5c4b894c578f9f0bc9","metadata":{"doi":"10.1016/j.redox.2025.103563","pmcid":"PMC11909752","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr7.jpg","type":"external","tracked_at":"2026-04-23T01:08:31.442862"},"caption":"Cardiac-specific PDE4D-knockdown activates mitophagy and protects against TAC-induced cardiac hypertrophy and heart failure . A,  30 days after TAC or sham surgery, αMHC-Cre+/PDE4D-flox/+ mice were subjected to a single intraperitoneal injection of tamoxifen (100 mg/kg/day) for 5 consecutive days to induce PDE4D ablation in the heart (PDE4D hCKO ). Littermate PDE4D-WT with the same dose of tamoxifen as controls. The mice were sacrificed 12 days after tamoxifen injection.  B  and  C,  Ejection fraction ( B ) and fractional shortening ( C ) were measured by echocardiography at 6 weeks after TAC; n = 8 mice per group.  D,  Cardiac cross-sections were stained with hematoxylin-eosin or WGA to examine heart morphology and measure myocyte CSA; n = 100 cells per heart and n = 3 mice per group. Scale bar, 50 μm. The myocardial apoptosis was detected by TUNEL staining, 2 random fields per heart; n = 3 mice per group. Scale bar, 50 μm. ROS levels were determined by DHE fluorescence intensity in t","paper_id":"9a10f9ee-2201-47b2-a4ca-b169666a53d9","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr7.jpg","image_path":"","description":"","figure_label":"Fig. 7","figure_number":8,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-22T18:08:31.442978-07:00","updated_at":"2026-04-22T18:08:31.442978-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr7.jpg","lifecycle_changed_at":"2026-04-22T18:08:31.442978-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5afa8a26-8d08-4814-bfd4-6850001e7391","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-9a10f9ee-2201-47b2-a4ca-b169666a53d9-8","is_canonical":true,"supersede_chain":["paper-fig-9a10f9ee-2201-47b2-a4ca-b169666a53d9-8"]}