{"artifact":{"id":"paper-fig-ab0b8f97-7861-478a-bb45-636e03c5ccd9-1","artifact_type":"paper_figure","entity_ids":"[]","title":"FIG. 1. — Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B?","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"ab0b8f97-7861-478a-bb45-636e03c5ccd9\", \"timestamp\": \"2026-04-22T01:29:40.999652\"}]","content_hash":null,"metadata":{"pmid":"ab0b8f97-7861-478a-bb45-636e03c5ccd9","caption":"Model for autoantigen presentation in B-cell–depleted NOD mice. Autoantigen presentation is normally balanced between B-cells and dendritic cells (DCs) in mice ( 16 ).  A : NOD autoantigen presentation. However, B-cell cognate presentation of pancreatic autoantigens may dominate in NOD mice because B-cell selection ( 17 ) and innate cell APC function are impaired ( 18 ). As a result, B-cell–driven pathogenic CD4 +  T-cell expansion and effector function leads to β-cell destruction and insulin deficiency.  B : Presentation without B-cells. Mature B-cell depletion in NOD mice eliminates the initiating role of B-cells in disease pathogenesis but shifts antigen presentation to other APCs that may reduce CD4 +  T-cell activation in favor of Treg induction or expansion and lead to a tolerogenic state or honeymoon period without disease.  C : Following B-cell reconstitution, previously induced Tregs may limit autoreactive T-cell activation and expansion, thereby enforcing long-term tolerance ","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC2699866/bin/zdb0070957820001.jpg","paper_title":"Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B?","figure_label":"FIG. 1.","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"2bb614f3-f067-4a4e-a407-5e461f9c59b3","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-ab0b8f97-7861-478a-bb45-636e03c5ccd9-1","is_canonical":true,"supersede_chain":["paper-fig-ab0b8f97-7861-478a-bb45-636e03c5ccd9-1"]}