{"artifact":{"id":"paper-fig-d651da98-16e1-4493-81d8-3ed9f9d6010e-4","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 4 — Transfer of mitochondria from astrocytes to neurons after stroke.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"d651da98-16e1-4493-81d8-3ed9f9d6010e\", \"timestamp\": \"2026-04-22T01:29:41.192889\"}]","content_hash":null,"metadata":{"pmid":"d651da98-16e1-4493-81d8-3ed9f9d6010e","caption":"Effects of CD38 siRNA in focal cerebral ischemia a,  Male C57Bl6 mice were subjected to transient 60 min focal\nischemia and control siRNA or CD38 siRNA was injected into lateral ventricles at\n5 days post-stroke. Immunostaining showed that CD38 siRNA decreased HMGB1\nastrocytes in peri-infarct cortex.  b,  Nissl staining showed no\ndifference in infarct size (n=8 or 10).  c,  Immunostaining\ndemonstrated that astrocytic CD38 was diminished by CD38 siRNA.  d, \nAstrocytic CD38 suppression with siRNA reduced GFAP-positive mitochondria in CSF\nat 7 days (n=6).  e,  Neuronal mitochondria were decreased by\nCD38 siRNA (n= 8 or 5).  f,  CD38 siRNA attenuated\nperi-infarct GAP43 immunostaining.  g,  Western blot confirmed a\nreduction of peri-infarct GAP43 protein within CD38 siRNA-treated brains\n(n=5).  h, i,  Suppression of CD38 signaling worsened\nneurological outcomes in neuroscore ( h ) and grid walking test\n( i ) (n=7 or 9).* P <0.05 vs\nday 3 control siRNA,  # P <0.05 vs day 7\nCD38 siRNA.  j,  CD","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC4968589/bin/nihms795847f4.jpg","paper_title":"Transfer of mitochondria from astrocytes to neurons after stroke.","figure_label":"Fig. 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"6d4bab96-065c-400f-989c-ec4a76e40158","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-d651da98-16e1-4493-81d8-3ed9f9d6010e-4","is_canonical":true,"supersede_chain":["paper-fig-d651da98-16e1-4493-81d8-3ed9f9d6010e-4"]}