{"artifact":{"id":"paper-fig-f224acb2-095b-423e-980a-e4cb8c8f61c8-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 1: GAS6 KO mice were more susceptible to JEV infection peripherally. Gas6  −/−  and...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"f224acb2-095b-423e-980a-e4cb8c8f61c8\", \"relation\": \"extracted_from\"}]","content_hash":"d3bb31062fd0ee1772357397617750ff8433ac7a0cf60b70ea7d8faf9b6c0945","metadata":{"doi":"10.1186/s12974-024-03225-1","pmcid":"PMC11411859","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig1_HTML.jpg","type":"external","tracked_at":"2026-04-23T01:14:24.927433"},"caption":"GAS6 KO mice were more susceptible to JEV infection peripherally. Gas6  −/−  and WT mice were infected with JEV at 10 6  PFU via foot pad injection. A, B, C. The survival rate ( A ), behavioural scores ( B ), and weight ( C ) of each group were recorded daily (gas6 KO  n  = 11; WT  n  = 8). D, F. The viral loads in gas6 −/−  and WT mouse brains at 3 dpi ( D ) and 5 dpi ( F ) were detected using qPCR (gas6 −/− n  = 5; WT  n  = 6). Data were normalised to β-actin and the relative change of viral copies was calculated based on the viral level of WT- d3- 1 or WT- d5- 1. Data are shown as mean ± SD. E, G. Relative expression of proinflammatory cytokines (TNF-α, CCL2, IFN-γ, IL-1β, IL-6) in gas6 −/−  and WT mouse brains at 3 dpi ( E ) and 5 dpi ( G ) were detected by qPCR (gas6 −/− n  = 5; WT  n  = 6). The data were normalised to β-actin and the relative change of expression was calculated based on the level of WT-d3-1 or WT-d5-1. Data are shown as mean ± SD","paper_id":"f224acb2-095b-423e-980a-e4cb8c8f61c8","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig1_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-22T18:14:24.927512-07:00","updated_at":"2026-04-22T18:14:24.927512-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig1_HTML.jpg","lifecycle_changed_at":"2026-04-22T18:14:24.927512-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"83d1fb97-8861-41be-992b-c33f39fed4d4","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-f224acb2-095b-423e-980a-e4cb8c8f61c8-1","is_canonical":true,"supersede_chain":["paper-fig-f224acb2-095b-423e-980a-e4cb8c8f61c8-1"]}