{"artifact":{"id":"paper-fig-f224acb2-095b-423e-980a-e4cb8c8f61c8-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 2: AXL, MERTK, or AM deleted mice were vulnerable to JEV attack with aggravated neu...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"f224acb2-095b-423e-980a-e4cb8c8f61c8\", \"relation\": \"extracted_from\"}]","content_hash":"4e47d99a43f52278e956974cc6f076b0a0e0f4b6824e218df92c156392d5450b","metadata":{"doi":"10.1186/s12974-024-03225-1","pmcid":"PMC11411859","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig2_HTML.jpg","type":"external","tracked_at":"2026-04-23T01:14:24.967469"},"caption":"AXL, MERTK, or AM deleted mice were vulnerable to JEV attack with aggravated neuroinflammation.  A . AXL −/− , MERTK  −/− , AM −/− , and WT mice were infected with JEV at 10 6  PFU. The survival rates of AXL −/− , MERTK −/−  and AM −/−  mice were all 0%, and that of WT mice was 36%. The median survival times of AXL −/− , MERTK −/− , AM −/− , and WT mice were 5.5, 7.5, 8, and 12 days respectively.  B . AXL −/− , MERTK −/− , AM −/− , and WT mice were infected with JEV at 10 5  PFU; the survival proportions of AXL −/− , MERTK −/− , and AM −/−  mice were 6.67%, 0%, and 14.29%, while that of WT mice was 38.46%; the median survival times were 7.5, 11, 9, and 15 days, respectively. AXL −/−  and WT mice were infected with JEV at 10 6  PFU, and the brains from each group were harvested for HE staining and proinflammatory cytokine detection at 3 and 5 dpi.  C . Histopathological changes in the meninges and cerebral cortex in each group. The meninges thickened after JEV infection, as indicated by","paper_id":"f224acb2-095b-423e-980a-e4cb8c8f61c8","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig2_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-22T18:14:24.967578-07:00","updated_at":"2026-04-22T18:14:24.967578-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11411859/bin/12974_2024_3225_Fig2_HTML.jpg","lifecycle_changed_at":"2026-04-22T18:14:24.967578-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"05a9a8ae-69b9-49aa-af41-75759644b15b","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-f224acb2-095b-423e-980a-e4cb8c8f61c8-2","is_canonical":true,"supersede_chain":["paper-fig-f224acb2-095b-423e-980a-e4cb8c8f61c8-2"]}