{"artifact":{"id":"paper-fig-paper-07c5d7883c4f-1","artifact_type":"paper_figure","entity_ids":"[]","title":"FIGURE 1 — Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline ","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-07c5d7883c4f\", \"timestamp\": \"2026-04-22T01:29:42.299825\"}]","content_hash":null,"metadata":{"pmid":"paper-07c5d7883c4f","caption":"GJA1  is identified as one of the crucial genes for ventricular arrhythmias. (A) Venn diagram of the ventricular arrhythmia (VA) putative genes (PVC: premature ventricular contraction; VT: ventricular tachycardia; Vf: ventricular flutter; and VF: ventricular fibrillation) obtained from the OMIM and DisGeNET databases. (B) Visualization of the protein–protein interaction (PPI) network of the obtained genes from Panel A, and top 20 hub genes identified by six algorithms including Stress, MNC, EPC, Degree, Radiality, and Betweenness. The list of genes included in the algorithm is provided in Table  S1 . (C) Upset plot displaying six VA genes identified by external data ( GSE33165 ) and hub genes. Details of the external patient cohort are provided in Table  S2 . (D) Bar graph to compare the mRNA expression of  GJA1  in left ventricle (LV) between patients with sinus rhythm (SR,  n  = 5) and VA ( n  = 8). We averaged the epicardial and endocardial expression values from three nonischemic h","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13045320/bin/ADVS-13-e16090-g006.jpg","paper_title":"Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism.","figure_label":"FIGURE 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5429bd99-713c-4e5c-b0ac-efcb53dde74f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-07c5d7883c4f-1","is_canonical":true,"supersede_chain":["paper-fig-paper-07c5d7883c4f-1"]}