{"artifact":{"id":"paper-fig-paper-18d2a490986a-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 1 — Potent and specific MTH1 inhibitors targeting gastric cancer.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-18d2a490986a\", \"timestamp\": \"2026-04-22T01:29:42.714209\"}]","content_hash":null,"metadata":{"pmid":"paper-18d2a490986a","caption":"Characteristic expression of MTH1 in human gastric cancer tissues and ten digestive tract cancer cell lines. a  The total RNA from fresh human gastric cancer tissues was isolated by RNApure Tissue&Cell Kit. The mRNA level of MTH1 in human gastric cancer (Increased,  n  = 21, Decreased,  n  = 6 and Unchanged,  n  = 8) and adjacent normal tissues (Con,  n  = 35) was determined by RT-PCR. The protein levels of MTH1 in human gastric (GC) and adjacent normal (GN) tissue sections were determined by immuohistochemistry (IHC) staining. The integral optical densities (IOD) were analyzed by Image-Pro Plus 6.0 software.  b  Representative IHC pictures of GC and GN. Scale bars, 50 μm.  c  IODs of GC and GN.  n  = 10 for each group. The cells from esophageal cancer cell lines: KYSE-450, EC109 and EC9706 ( d ,  e ), liver cancer cell lines: SMMC-7721, HepG2 and ZIP177 ( f ,  g ), gastric cancer cell lines: MGC-803, HGC-27, SGC-7901 and MKN45 ( h ,  i ), as well as the corresponding normal cell lines","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig1_HTML.jpg","paper_title":"Potent and specific MTH1 inhibitors targeting gastric cancer.","figure_label":"Fig. 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"dd83355e-d522-4f9e-a7ef-132b61a25b77","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-18d2a490986a-1","is_canonical":true,"supersede_chain":["paper-fig-paper-18d2a490986a-1"]}