{"artifact":{"id":"paper-fig-paper-18d2a490986a-3","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 3 — Potent and specific MTH1 inhibitors targeting gastric cancer.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-18d2a490986a\", \"timestamp\": \"2026-04-22T01:29:42.716120\"}]","content_hash":null,"metadata":{"pmid":"paper-18d2a490986a","caption":"The cytotoxicities of compounds MI-743 and MI-929 on 16 cancer cell lines. a  Four normal cell lines and above reported cancer cell lines were treated with different concentrations of MI-743 and MI-929 for 72 h. Cell viability was determined by MTT assay, using DMSO-treated controls. IC 50  values are indicated as the means ± SD of three independent experiments. TH588 and (S)-crizotinib were used as positive control.  b  The colony formations of MGC-803, HGC-27 and GES-1 cells were determined after being treated with 0.5, 2, 4, 8 and 10 µM of compound MI-743. At least three independent experiments were performed for each group.  c ,  d  Clonogenic survival rates of gastric cancer cell lines after MI-743 and MI-929 treatments were determined by measuring the absorbance values at 595 nm in relation to DMSO-treated controls. TH588 and (S)-crizotinib were used as positive control. Data are presented as means ± SD. Three individual experiments were performed for each group. * P  < 0.05, ** ","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig3_HTML.jpg","paper_title":"Potent and specific MTH1 inhibitors targeting gastric cancer.","figure_label":"Fig. 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"34e403dd-2493-4085-a1fe-c9266e184228","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-18d2a490986a-3","is_canonical":true,"supersede_chain":["paper-fig-paper-18d2a490986a-3"]}