{"artifact":{"id":"paper-fig-paper-18d2a490986a-6","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 6 — Potent and specific MTH1 inhibitors targeting gastric cancer.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-18d2a490986a\", \"timestamp\": \"2026-04-22T01:29:42.718447\"}]","content_hash":null,"metadata":{"pmid":"paper-18d2a490986a","caption":"The anti-proliferative activity of MI-743 on gastric cancer xenografts. Gastric cancer cells MGC-803 were transplanted subcutaneously to the right side of BALB-C nude mice. When most of the tumor volumes reached 100 mm 3 , the mice were treated with oil or compound MI-743(40 mg/kg, once a day) for 25 days.  a  The average tumor weight.  b  The tumor volumes were measured every 4 days. ( c ) The mice body weights were measured every 2 days.  d ,  e  The tumor tissues were collected and fixed in 4% buffered paraformaldehyde and paraffin-embedded for immunohistochemistry to detect the protein level of 8-oxo-dG and ATMpS1981 ( e ), H&E staining to observe the cell morphology and TUNEL staining to examine apoptosis status ( d ). Pictures for immunohistochemistry and H&E staining were originally captured at ×200 and ×400 magnification. Pictures for TUNEL staining were originally captured at ×400 magnification.  f  The mice major organs were collected and fixed in 4% buffered paraformaldehyde","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig6_HTML.jpg","paper_title":"Potent and specific MTH1 inhibitors targeting gastric cancer.","figure_label":"Fig. 6","figure_number":6,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d92ca9b5-10a9-4904-a907-6f34ee0774af","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-18d2a490986a-6","is_canonical":true,"supersede_chain":["paper-fig-paper-18d2a490986a-6"]}