{"artifact":{"id":"paper-fig-paper-18d2a490986a-8","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 8 — Potent and specific MTH1 inhibitors targeting gastric cancer.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-18d2a490986a\", \"timestamp\": \"2026-04-22T01:29:42.721491\"}]","content_hash":null,"metadata":{"pmid":"paper-18d2a490986a","caption":"Proposed mechanisms for MI-743 induced cell death in gastric cancer cells MGC-803 and HGC-27 through targeting MTH1. In gastric cancer cells MGC-803 and HGC-27(left), increased ROS convert dGTP and dATP to 8-oxo-dGTP and 2-OH-dATP, respectively. The overexpressed MTH1 hydrolyzes the oxidized triphosphates into the corresponding 8-oxo-dGMP and 2-OH-dAMP, in order to prevent their incorporation into double strand DNA and further maintain cancer cell survival. However, under the treatment of compound MI-743(right), the enhanced activity of MTH1 in cancer cells is inhibited. The oxidized nucleotides (8-oxo-dGTP and 2-OH-dATP) will be incorporated into DNA, which further causes double strand DNA damage and finally induces cell death","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig8_HTML.jpg","paper_title":"Potent and specific MTH1 inhibitors targeting gastric cancer.","figure_label":"Fig. 8","figure_number":8,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"6d011066-5d84-41ec-89ef-1230877b6e9f","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-18d2a490986a-8","is_canonical":true,"supersede_chain":["paper-fig-paper-18d2a490986a-8"]}