{"artifact":{"id":"paper-fig-paper-1a913d80f239-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 2 — Single-cell RNA sequencing reveals distinct immunology profiles in human keloid.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-1a913d80f239\", \"timestamp\": \"2026-04-22T01:29:42.184896\"}]","content_hash":null,"metadata":{"pmid":"paper-1a913d80f239","caption":"Fibroblasts of keloid and normal skin tissue subcluster into distinct cell populations.  (A)  Subclustering of keloid and normal tissue fibroblasts identified four distinct subtypes: mesenchymal (MF), pro-inflammatory (PF), secretory-papillary (SPF), and secretory-reticular (SRF).  (B)  Demonstration of the ratio of the four fibroblast subpopulations in keloids and adjacent normal tissue.  (C)  Color-coded UMAP plot is shown, and each fibroblast subcluster is defined.  (D)  Heatmap plots showing representative differentially expressed genes between the four fibroblasts in the keloids.  (E)  Gene ontology (GO) biological process enrichment analysis of differentially expressed genes in the four fibroblasts between keloid and normal scars.  (F)  GO enrichment analysis of differentially expressed genes in mesenchymal fibroblasts.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC9381754/bin/fimmu-13-940645-g002.jpg","paper_title":"Single-cell RNA sequencing reveals distinct immunology profiles in human keloid.","figure_label":"Figure 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"6bdd6e32-0524-4295-892f-290e57c06998","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-1a913d80f239-2","is_canonical":true,"supersede_chain":["paper-fig-paper-1a913d80f239-2"]}