{"artifact":{"id":"paper-fig-paper-2b837133a8d7-4","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 4 — A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-2b837133a8d7\", \"timestamp\": \"2026-04-22T01:29:41.803034\"}]","content_hash":null,"metadata":{"pmid":"paper-2b837133a8d7","caption":"A roadmap proposed toward personalized immunology. There exist both horizontal and vertical roadmaps toward personalized immunology. Vertically, to translate sample stratification to clinical therapies, it is necessary to utilize the state-of-the-art “Omics” analysis and network integration approaches to stratify patients into subgroups and then implement personalized therapeutic approaches to treat individual patients, which needs to overcome various types of barriers at different steps. Horizontally, it might be necessary to go through at least seven steps to enable personalized immunotherapies: (1) classic symptom-based approach, (2) deep phenotyping approach, (3) multilayer “Omics”-based profiling, (4) cell-type-specific “Omics,” (5) state-specific “Omics,” (6) single-cell “Omics” and dynamic response analysis of immune cells, and (7) integrated network analysis. Under the first layer (the so-called stratification layer), different colors of patients indicate individual patients wi","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC7137904/bin/fimmu-11-00456-g0004.jpg","paper_title":"A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease.","figure_label":"Figure 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"64bada06-14b2-47e7-ad89-55fa69848590","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-2b837133a8d7-4","is_canonical":true,"supersede_chain":["paper-fig-paper-2b837133a8d7-4"]}