{"artifact":{"id":"paper-fig-paper-2ce452f1-1eac-4e56-a7a0-abf3bc640f1e-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 2 — Sporadic autism exomes reveal a highly interconnected protein network of de novo","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-2ce452f1-1eac-4e56-a7a0-abf3bc640f1e\", \"timestamp\": \"2026-04-27T06:22:45.713326\"}]","content_hash":null,"metadata":{"pmid":"paper-2ce452f1-1eac-4e56-a7a0-abf3bc640f1e","caption":"a  The 49-gene connected component of the PPI network formed from 126 genes with severe  de novo  mutations among the 209 probands.  b,  Proband 13844 inherits three rare gene-disruptive CNVs and carries two  de novo  truncating mutations.  c,  GeneMANIA  21   view of three of the affected genes ( b ) (red labels) which encode proteins that are part of a beta-catenin linked network. This proband is macrocephalic, impaired cognitively, and has deficits in social behavior and language development ( Supplementary Discussion ).","image_url":"","paper_title":"Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations","figure_label":"Figure 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_xml"},"created_at":"2026-04-26T23:22:43.799915-07:00","updated_at":"2026-04-26T23:22:43.799915-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-26T23:22:43.799915-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"470e4fc1-7413-4f2a-92e9-72d3871e8366","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-2ce452f1-1eac-4e56-a7a0-abf3bc640f1e-2","is_canonical":true,"supersede_chain":["paper-fig-paper-2ce452f1-1eac-4e56-a7a0-abf3bc640f1e-2"]}