{"artifact":{"id":"paper-fig-paper-40988129-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 2 — Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-40988129\", \"timestamp\": \"2026-04-22T01:29:42.247184\"}]","content_hash":null,"metadata":{"pmid":"paper-40988129","caption":"CSF levels of MMP-9, tissue damage markers and complement factors in acute myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS) and symptomatic controls (SC) . Box plots showing CSF concentrations of matrix metalloproteinase-9 (MMP-9;  A ), neurofilament light chain (NfL;  B ), glial fibrillary acidic protein (GFAP;  C ), S100 calcium-binding protein B (S100B;  D ), complement factor C5 ( E ) and complement activation product C5a ( F ) across patient groups. Data are presented on a double logarithmic scale ( y -axis; concentrations in pg/ml, except for C5 in ng/ml). Statistical comparisons were performed using the Wilcoxon rank-sum test; significance thresholds are denoted as: ns (not significant),  P  > 0.05; * P  ≤ 0.05; ** P  ≤ 0.01; *** P  ≤ 0.001; **** P  ≤ 0.0001.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13058455/bin/awaf345f2.jpg","paper_title":"Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyelitis optica from multiple sclerosis.","figure_label":"Figure 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"65dfded0-c89f-4641-b5f5-1431f75abbc2","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-40988129-2","is_canonical":true,"supersede_chain":["paper-fig-paper-40988129-2"]}