{"artifact":{"id":"paper-fig-paper-40988129-3","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 3 — Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-40988129\", \"timestamp\": \"2026-04-22T01:29:42.248201\"}]","content_hash":null,"metadata":{"pmid":"paper-40988129","caption":"Modelled kinetics of granulocyte activation markers (GAM) in CSF over 60 days following disease exacerbation . Modelled CSF levels of neutrophil elastase (nEla), myeloperoxidase (MPO), matrix metalloproteinase-8 (MMP-8) and neutrophil gelatinase-associated lipocalin (NGAL) are shown for neuromyelitis optica spectrum disorder (NMOSD) (orange line), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) (blue line) and multiple sclerosis (MS) (red line). The  x -axis represents days post-exacerbation (0–60 days), with the vertical dashed line marking the transition from the acute (≤21 days) to the subacute/chronic stage (>21 days). Biomarker values ( y -axis) are plotted in pg/ml on a log-transformed scale. Solid lines represent modelled trajectories, with shaded areas denoting 95% confidence intervals. Distinct kinetic patterns are observed: Pattern 1 (nEla, MPO, MMP-8) shows early elevation in MOGAD and NMOSD but relative stability in MS; Pattern 2 (NGAL) shows early e","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13058455/bin/awaf345f3.jpg","paper_title":"Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyelitis optica from multiple sclerosis.","figure_label":"Figure 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"9f8ea227-5457-4f04-911a-d0ee9aed1597","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-40988129-3","is_canonical":true,"supersede_chain":["paper-fig-paper-40988129-3"]}