{"artifact":{"id":"paper-fig-paper-40988129-6","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 6 — Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-40988129\", \"timestamp\": \"2026-04-22T01:29:42.253578\"}]","content_hash":null,"metadata":{"pmid":"paper-40988129","caption":"Proposed diagnostic flow chart for differentiating MOGAD, NMOSD and MS based on CSF biomarkers.  Flow diagram illustrating a proposed decision pathway for the differential diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) in patients presenting with acute clinical worsening and MRI evidence of new lesion formation. Initial separation is based on CSF levels of granulocyte activation markers (GAM) and complement factors C5/C5a. If elevated, differentiation between MOGAD and NMOSD is guided by astrocytic damage markers GFAP and S100B. Absence of biomarker increases suggests a diagnosis of MS.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13058455/bin/awaf345f6.jpg","paper_title":"Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyelitis optica from multiple sclerosis.","figure_label":"Figure 6","figure_number":6,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d691cd9c-2c59-4546-96f9-bdf57dcfb360","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-40988129-6","is_canonical":true,"supersede_chain":["paper-fig-paper-40988129-6"]}