{"artifact":{"id":"paper-fig-paper-41665955-1","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 1 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-41665955\", \"timestamp\": \"2026-04-22T01:29:42.306865\"}]","content_hash":null,"metadata":{"pmid":"paper-41665955","caption":"Neutrophils infiltrating and extruding extracellular traps (NETosis) in NMO mouse spinal cord. ( A ) Experimental design: catheter inserted via cisterna magna into L4 subarachnoid space (yellow circle, Evans blue verification). Subcutaneous osmotic pump continuously infuses AQP4-IgG or control mouse IgG (1.2 μg/d, in 12 μL). Rotarod motor training, days –3, –2, –1; testing, days 0, +1, +2, +3, +4, and +5. Terminal transcardiac perfusion: cord harvested for immunohistochemical and flow cytometric analyses. ( B ) Cord-infiltrating neutrophils (Cytek analysis), IgG infusion days 1, 3, and 5. Control mice (first panel) infused 3 days with normal mouse IgG. AQP4-IgG recipients: panels 2–4 (3 mice/group). t-SNE, t-distributed stochastic neighbor embedding. ( C – E ) IgG infusion day 3: representative images ( C  and  D ) and quantification ( E ) of neutrophils (Ly6G + MPO + ) in lumbar parenchyma (4 mice/group). Higher magnification box in  C  shows neutrophils (magenta) and nuclei (blue). (","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g001.jpg","paper_title":"Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG.","figure_label":"Figure 1","figure_number":1,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5db40a72-aa91-443f-9131-72000dcba644","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41665955","link_type":"cites","strength":0.9,"evidence":"paper_figure.metadata.pmid=paper-41665955"}],"incoming_links":[],"current_artifact_id":"paper-fig-paper-41665955-1","is_canonical":true,"supersede_chain":["paper-fig-paper-41665955-1"]}