{"artifact":{"id":"paper-fig-paper-41665955-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 2 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-41665955\", \"timestamp\": \"2026-04-22T01:29:42.307902\"}]","content_hash":null,"metadata":{"pmid":"paper-41665955","caption":"Neutrophil-microglial contacts in lumbar parenchyma, AQP4-IgG infusion day 3. ( A ) Confocal image identifies putatively interacting microglia (Cx3cr1GFP + , green) and neutrophil (Ly6G + , red) adjacent to a neuronal soma (NeuN + , blue); subsequent images are Imaris 3D rendering. ( B ) Cord region of interest containing contacting neutrophil-microglia; laser-branded frame by 2-photon imaging; magnified. ( C ) Serial block-face scanning electron microscopy (SBF-SEM) shows ultrastructurally the same neutrophil, microglia, and 2 neurons boxed in  A . Yellow arrows (magnified,  C1 ) indicate contacting microglial-neutrophil somata edges (green and red lines in  C2 ). ( D ) 3D serial reconstruction of contacting microglial-neutrophil somata in  C  ( Supplemental Video 1 ,  Z -stack). ( E ) Representative confocal image (left, 2,048 × 2,048 pixel; ×63 objective lens) and 3D rendering image (right) show microglial process and soma interacting with Ly6G +  neutrophils in lumbar parenchyma of","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g002.jpg","paper_title":"Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG.","figure_label":"Figure 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d16f598a-f278-4a9e-b414-77c721b6278d","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41665955","link_type":"cites","strength":0.9,"evidence":"paper_figure.metadata.pmid=paper-41665955"}],"incoming_links":[],"current_artifact_id":"paper-fig-paper-41665955-2","is_canonical":true,"supersede_chain":["paper-fig-paper-41665955-2"]}