{"artifact":{"id":"paper-fig-paper-41665955-6","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 6 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-41665955\", \"timestamp\": \"2026-04-22T01:29:42.311677\"}]","content_hash":null,"metadata":{"pmid":"paper-41665955","caption":"C5ar1  deficiency ameliorates neuronal dysfunction and lipid droplet accumulation in motor neurons. ( A ) Experimental design: mice were infused continuously with AQP4-IgG using osmotic pumps from day 0 through day 7. ( B – D ) Quantification of Nissl bodies ( B ), Nissl area ( C ), and percentage area occupied by ChAT +  motor neurons in gray matter of lumbar cord of Ctrl-IgG–infused mice at day 3, AQP4-IgG–infused mice at days 3, 14, and 28. ( E – H ) Representative images of Nissl bodies (red) in ventral gray matter (vGM) neurons of wild-type and  C5ar1 –/–  mice at day 3. Boxed areas are enlarged on the right. ( I  and  J ) Numbers and sizes of Nissl body +  neurons in vGM ( n  = 8 mice per group). ( K ) Representative motor neuron confocal images and quantification in vGM of WT mice infused with Ctrl-IgG or AQP4-IgG and  C5ar1 –/–  mice infused with AQP4-IgG or control-IgG (not shown). HuD +  (green); ChAT +  (magenta). ( L  and  M ) Numbers of ChAT +  motor neurons (MNs) and thei","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g006.jpg","paper_title":"Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG.","figure_label":"Figure 6","figure_number":6,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"10b57f8f-d350-4bd8-96f6-1b6d07e54eff","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41665955","link_type":"cites","strength":0.9,"evidence":"paper_figure.metadata.pmid=paper-41665955"}],"incoming_links":[],"current_artifact_id":"paper-fig-paper-41665955-6","is_canonical":true,"supersede_chain":["paper-fig-paper-41665955-6"]}