{"artifact":{"id":"paper-fig-paper-41665955-8","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 8 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-41665955\", \"timestamp\": \"2026-04-22T01:29:42.313520\"}]","content_hash":null,"metadata":{"pmid":"paper-41665955","caption":"Disease-associated microglia interact with motor neurons in an NMO mouse model. ( A ) Representative immunostained images of motor neuron–associated (ChAT + ) microglia (IBA1 + ) in ventral gray matter of mice infused for 3 days with IgG infusion. Boxed areas are enlarged on the right. 3D rendering of boxed area in AQP4-IgG mice is shown as split confocal channels (lower right) and merged (lower center). ( B  and  C ) Quantification of microglia-neuron co-colocalization area ( B ) and volume ( C ) in  A  ( n  = 6 mice per group in  B ;  n  = 1,526 and 1,272 microglial contacts, respectively, for Ctrl-IgG and AQP4-IgG mice). ( D ) ImageJ analysis shows the percentage area occupied by Galectin-3 within contacting microglia is greater than in noncontacting microglia in lumbar cord of the 2 experimental groups. ( E ) Overlaid confocal images show microglial P2Y12 receptor (yellow), Galectin-3 marker of DAMs (cyan) contacting neurons in lumbar ventral gray matter of AQP4-IgG-infused mice, i","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g008.jpg","paper_title":"Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG.","figure_label":"Figure 8","figure_number":8,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"908552e9-746f-4430-bf0d-6feaf87677e3","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"paper-41665955","link_type":"cites","strength":0.9,"evidence":"paper_figure.metadata.pmid=paper-41665955"}],"incoming_links":[],"current_artifact_id":"paper-fig-paper-41665955-8","is_canonical":true,"supersede_chain":["paper-fig-paper-41665955-8"]}