{"artifact":{"id":"paper-fig-paper-41692246-4","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 4 — Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-41692246\", \"timestamp\": \"2026-04-22T01:29:42.052548\"}]","content_hash":null,"metadata":{"pmid":"paper-41692246","caption":"A: Histogram of the most abundant proteins measured in microglia ApoE lipoproteins. Abundance was determined by excluding common contaminants, showing differential expression compared to proteins measured in ApoE −/−  microglia-conditioned media, and the protein abundance being greater than the total mean + 0.5 standard deviation threshold. Error bars represent mean ± SEM. For proteomics analysis, the following groups were analyzed: ApoE2 microglia (n = 3), ApoE3 microglia (n = 3), and ApoE4 microglia (n = 4). B: PCA of the proteome of microglia ApoE lipoproteins. Circles are colored based on the ApoE isoform and represent the 95% confidence interval. Microglia samples show clear differences in the proteome of microglia-secreted ApoE lipoproteins based on the ApoE isoform. This finding is in contrast to the proteome of astrocyte ApoE lipoproteins, suggesting that the ApoE isoform plays a greater role in the proteome of microglia ApoE lipoproteins. C: Volcano plot showing differential p","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12996666/bin/gr4.jpg","paper_title":"Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform.","figure_label":"Fig. 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"dd3a3cc8-6127-465b-a16f-5265f2094ef8","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-41692246-4","is_canonical":true,"supersede_chain":["paper-fig-paper-41692246-4"]}