{"artifact":{"id":"paper-fig-paper-41899560-3","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 3 — TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas: Molecular Landscape and ","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-41899560\", \"timestamp\": \"2026-04-22T01:29:42.336583\"}]","content_hash":null,"metadata":{"pmid":"paper-41899560","caption":"Suggested diagnostic workflow for suspected MiT family renal cell carcinoma (MiT-RCC). The algorithm integrates clinical-pathologic suspicion, confirmation of renal origin, an immunohistochemistry (IHC) screening panel ( TFE3 ,  TFEB , and GPNMB), confirmatory break-apart fluorescence in situ hybridization (FISH) for rearrangements where appropriate, and advanced molecular testing (RNA-based fusion assays,  TRIM63  RNA in situ hybridization (RNA-ISH), and copy-number assessment for  TFEB / VEGFA  amplification) in equivocal cases. Abbreviations: EMA, epithelial membrane antigen; FISH, fluorescence in situ hybridization; GPNMB, glycoprotein NMB; IHC, immunohistochemistry; panCK, pancytokeratin; PAX2, paired box gene 2; PAX8, paired box gene 8; PEComa, perivascular epithelioid cell neoplasm; RNA-ISH, RNA in situ hybridization; RT-PCR, reverse transcription polymerase chain reaction; SMA, smooth muscle actin; S100, S100 protein; SOX10, SRY-box transcription factor 10;  VEGFA , vascular en","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC13025244/bin/cancers-18-00958-g003.jpg","paper_title":"TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas: Molecular Landscape and Therapeutic Advances.","figure_label":"Figure 3","figure_number":3,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"617ba7c3-eb98-41e4-b166-4dcb3147fc7b","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-41899560-3","is_canonical":true,"supersede_chain":["paper-fig-paper-41899560-3"]}