{"artifact":{"id":"paper-fig-paper-486e714f1641-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 2. — Microglia, Trem2, and Neurodegeneration.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-486e714f1641\", \"timestamp\": \"2026-04-22T01:29:42.218178\"}]","content_hash":null,"metadata":{"pmid":"paper-486e714f1641","caption":"Domain structure of the Trem2 protein and its association with Alzheimer disease (AD) risk. ( A ) Human Trem2 protein domain structure: this schematic illustrates the structural domains of the human Trem2 protein, including the signal peptide (SP), transmembrane domain (TM), and C-terminal tail (CT). Notable are the common variants associated with AD risk and the cleavage sites for ADAM17/10, which are crucial for Trem2’s functional modulation in the disease context. ( B ) Membrane-bound three-dimensional (3D) structure of Trem2-DAP12 complex: derived from AlphaFold (ID:  Q9NZC2 ), this representation showcases the 3D conformation of Trem2 as it anchors to the cell membrane through a transmembrane helix. TREM2’s interaction with DAP12 (AlphaFold ID:  O43914 ) is highlighted, showing electrostatic interactions (involving lysine and arginine residues) within the transmembrane domains. Additionally, the dimerization of two DAP12 proteins through a disulfide bond is depicted, emphasizing t","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC11576490/bin/10.1177_10738584241254118-fig2.jpg","paper_title":"Microglia, Trem2, and Neurodegeneration.","figure_label":"Figure 2.","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"a39e499d-b9b0-4135-a850-078dda445973","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-486e714f1641-2","is_canonical":true,"supersede_chain":["paper-fig-paper-486e714f1641-2"]}