{"artifact":{"id":"paper-fig-paper-5839e7d0e39b-4","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 4 — Small nucleoli are a cellular hallmark of longevity.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-5839e7d0e39b\", \"timestamp\": \"2026-04-22T01:29:42.542972\"}]","content_hash":null,"metadata":{"pmid":"paper-5839e7d0e39b","caption":"Smaller nucleoli associate with longevity in higher organisms. ( a , b ) DR,  dilp2-3,5  and Rapamycin treated  D. melanogaster  possess small nucleoli in intestine and fat body (Error bars represent mean±s.d.). ( c , d ) DR and IRS1 knockout mice show reduced nucleolar size in kidney tissue compared to ad libitum fed mice and wildtype (Error bars represent mean±s.d.). ( e , f ) Muscle biopsies from humans undergoing DR and exercise exhibit small nucleoli. Scale bars represent 10 μm ( a , c ) and 20 μm ( e ). * P <0.05 paired t-test, **** P <0.0001 unpaired t-test.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC5582349/bin/ncomms16083-f4.jpg","paper_title":"Small nucleoli are a cellular hallmark of longevity.","figure_label":"Figure 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e59e02db-f620-4041-b1bd-1d64a118031e","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-5839e7d0e39b-4","is_canonical":true,"supersede_chain":["paper-fig-paper-5839e7d0e39b-4"]}