{"artifact":{"id":"paper-fig-paper-6ec76a6d668d-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 2 — RNA splicing and splicing regulator changes in prostate cancer pathology.","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-6ec76a6d668d\", \"timestamp\": \"2026-04-22T01:29:42.504958\"}]","content_hash":null,"metadata":{"pmid":"paper-6ec76a6d668d","caption":"Prostate tissue visualised using tissue biopsies.  a ,  b . Histological sections made from benign prostatic hyperplasia (BPH, with normal glandular structure embedded in stroma). Prostate cancer development is clinically described as a series of Gleason grades (1–5, with 1 corresponding to well-differentiated tissue containing a glandular structure and 5 being the most advanced with only few glands still visible) (Gleason and Mellinger  1974 ; Mellinger et al.  1967 ).  c ,  d  Histological sections made from prostate cancer (Gleason grade 5, notice breakdown of glandular structure). Left panels, sections processed using H&E staining. Right panels, sections processed by staining with haematoxylin and counterstaining with the RNA-binding protein Sam68 ( brown stain ). Figure adapted from (Rajan et al.  2008 ) with permission from the Journal of Pathology","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC5602090/bin/439_2017_1792_Fig2_HTML.jpg","paper_title":"RNA splicing and splicing regulator changes in prostate cancer pathology.","figure_label":"Fig. 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"68e182d8-e7e7-490f-90f6-48d5117b4eea","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-6ec76a6d668d-2","is_canonical":true,"supersede_chain":["paper-fig-paper-6ec76a6d668d-2"]}