{"artifact":{"id":"paper-fig-paper-755ca816b4f9-5","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 5: Microglial  Tbk1  deletion is sufficient to induce an FTD-like social recognitio...","quality_score":0.5,"created_by":"paper_figures_pipeline","provenance_chain":"[{\"source\": \"paper\", \"paper_id\": \"paper-755ca816b4f9\", \"relation\": \"extracted_from\"}]","content_hash":"3c30f8ba129a3c952c0db3a01786c284abeaaa9ee9a7cac167e965f411577456","metadata":{"doi":"10.1038/s41467-025-63211-w","pmcid":"PMC12381211","_origin":{"url":"https://www.ebi.ac.uk/europepmc/articles/PMC12381211/bin/41467_2025_63211_Fig5_HTML.jpg","type":"external","tracked_at":"2026-04-26T04:55:44.427594"},"caption":"Microglial  Tbk1  deletion is sufficient to induce an FTD-like social recognition deficit. a  Workflow of the 3-chamber test to assess presence of sociability and social recognition (social novelty preference) defects in 4-month-old male mice with microglial specific deletion of one (Tbk1-µG-HET) or two (Tbk1-µG-KO)  Tbk1  copies and compared to control littermates (Tbk1-µG-WT). Created in BioRender. Lenoel, I. (2025)  https://BioRender.com/ct8qnd6 .  b  Interaction times during the first three trials (trials 1–3) of the 3-chamber test (sociability phase).  n  = 12 mice per genotype (males only). Adjusted  p  values are indicated and were determined by a two-tailed type II Wald chi-square test with Tukey’s post hoc test. Results from trials 1–3 indicate no impairment of social interaction (sociability) due to microglial  Tbk1  deletion.  c  Representative heatmaps of the mouse positions during the social recognition phase of the 3-chamber test (trial 4), shown for Tbk1-µG-KO and contro","paper_id":"paper-755ca816b4f9","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12381211/bin/41467_2025_63211_Fig5_HTML.jpg","image_path":"","description":"","figure_label":"Fig. 5","figure_number":5,"_schema_version":1,"source_strategy":"pmc_api","entities_mentioned":""},"created_at":"2026-04-25T21:55:44.427722-07:00","updated_at":"2026-04-25T21:55:44.427722-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":"https://www.ebi.ac.uk/europepmc/articles/PMC12381211/bin/41467_2025_63211_Fig5_HTML.jpg","lifecycle_changed_at":"2026-04-25T21:55:44.427722-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"faf26436-c3f8-46a2-8f56-102c7ca2867c","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_pipeline"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-755ca816b4f9-5","is_canonical":true,"supersede_chain":["paper-fig-paper-755ca816b4f9-5"]}