{"artifact":{"id":"paper-fig-paper-796580b4c70c-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 2 — Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-796580b4c70c\", \"timestamp\": \"2026-04-22T01:29:42.475929\"}]","content_hash":null,"metadata":{"pmid":"paper-796580b4c70c","caption":"Expression of resolvin receptors ALX and ChemR23 in rat osteoarthritis (OA) joint tissue.  A  and  B,  Significant weight‐bearing asymmetry ( A ) and decreased ipsilateral paw withdrawal thresholds ( B ) following intraarticular injection of monosodium iodoacetate (MIA) into the knee joints (MIA‐treated rats) compared with saline‐treated control rats (n = 8 per group). Values are the mean ± SEM. ∗∗∗∗ =  P  < 0.0001 versus control, by two‐way analysis of variance with Bonferroni's post hoc test.  C  and  D,  Decreased synovial expression of ChemR23 in MIA‐treated rats compared with saline‐treated control rats on day 14 ( C ) and day 35 ( D ).  E  and  F,  Comparable expression of ALX in the synovium of MIA‐treated rats and saline‐treated rats on day 14 ( E ) and day 35 ( F ) (n = 7–8 per group). Bars in  C – F  show the mean ± SEM. ∗ =  P  < 0.05; ∗∗ =  P  < 0.01 by unpaired  t ‐test.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC5763389/bin/ART-69-996-g002.jpg","paper_title":"Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.","figure_label":"Figure 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"5399dd5d-2ecb-4d90-b68b-bade2fc5b804","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-796580b4c70c-2","is_canonical":true,"supersede_chain":["paper-fig-paper-796580b4c70c-2"]}