{"artifact":{"id":"paper-fig-paper-796580b4c70c-4","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 4 — Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-796580b4c70c\", \"timestamp\": \"2026-04-22T01:29:42.477144\"}]","content_hash":null,"metadata":{"pmid":"paper-796580b4c70c","caption":"Inhibition of pain behavior by the D series resolvin precursor 17(R)‐hydroxy‐docosahexaenoic acid (17[R]‐HDoHE).  A  and  B,  Attenuated weight‐bearing asymmetry ( A ) and decreased ipsilateral hind paw withdrawal thresholds ( B ) 14 days after model induction in rats treated with monosodium iodoacetate (MIA) + 17(R)‐HDoHE compared to MIA‐injected vehicle‐treated rats. Bars show the mean ± SEM (n = 8 per group). ## =  P  < 0.01; ### =  P  < 0.001 versus saline + vehicle. ∗ =  P  < 0.05; ∗∗∗ =  P  < 0.001; ∗∗∗∗ =  P  < 0.0001 versus MIA + vehicle, by two‐way analysis of variance (ANOVA) with Bonferroni's post hoc test.  C  and  D,  Sustained inhibition of weight‐bearing asymmetry ( C ) and decreased paw withdrawal thresholds ( D ) from day 14 to day 28 following repeated administration of 17(R)‐HDoHE in rats treated with MIA compared with rats treated with MIA+ vehicle. Bars show the mean ± SEM. ∗ =  P  < 0.05; ∗∗ =  P  < 0.01; ∗∗∗∗ =  P  < 0.0001 versus MIA + vehicle, by two‐way ANOVA ","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC5763389/bin/ART-69-996-g004.jpg","paper_title":"Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.","figure_label":"Figure 4","figure_number":4,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"fa53a39a-883b-4838-83a4-4bdec57049e9","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-796580b4c70c-4","is_canonical":true,"supersede_chain":["paper-fig-paper-796580b4c70c-4"]}