{"artifact":{"id":"paper-fig-paper-796580b4c70c-5","artifact_type":"paper_figure","entity_ids":"[]","title":"Figure 5 — Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-796580b4c70c\", \"timestamp\": \"2026-04-22T01:29:42.477801\"}]","content_hash":null,"metadata":{"pmid":"paper-796580b4c70c","caption":"No alteration of osteoarthritis joint pathology by 17(R)‐HDoHE (Res).  A–C,  Representative images of hematoxylin and eosin (H&E)–stained knee joint sections from rats treated with saline, MIA + vehicle (Veh), or MIA + 17(R)‐HDoHE. A, Chondropathy. Bars = 500 μm.  B,  Synovial inflammation. Bars = 100 μm.  C,  Osteoclastogenesis. Bars = 100 μm.  Black arrows  indicate areas of chondropathy and synovial inflammation;  yellow arrows  indicate osteoclastogenesis.  D–G,  Significant joint pathology at 28 days in rats treated with intraarticular injections of MIA compared with saline‐treated rats. Repeated administration of 17(R)‐HDoHE from day 14 to day 28 did not alter the chondropathy score ( D ), synovial inflammation ( E ), chondrocyte appearance ( F ), or number of tartrate‐resistant acid phosphatase (TRAP)–positive osteoclasts ( G ) in the MIA‐treated rats. Bars show the mean ± SEM. ∗ =  P  < 0.05; ∗∗ =  P  < 0.01; ∗∗∗ =  P  < 0.001 by one‐way ANOVA with Bonferroni's post hoc test (p","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC5763389/bin/ART-69-996-g005.jpg","paper_title":"Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.","figure_label":"Figure 5","figure_number":5,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"ed71b5e5-69d8-4408-a163-d0e0ac53a5ce","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-796580b4c70c-5","is_canonical":true,"supersede_chain":["paper-fig-paper-796580b4c70c-5"]}