{"artifact":{"id":"paper-fig-paper-8281d7c4ac82-2","artifact_type":"paper_figure","entity_ids":"[]","title":"Fig. 2 — A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa","quality_score":0.5,"created_by":"paper_figures_tool","provenance_chain":"[{\"step\": \"paper_figures_backfill\", \"pmid\": \"paper-8281d7c4ac82\", \"timestamp\": \"2026-04-22T01:29:42.774485\"}]","content_hash":null,"metadata":{"pmid":"paper-8281d7c4ac82","caption":"Amcp inhibited the proliferation of human pancreatic cancer cells. a  The chemical structure of Amcp.  b  The time- and dose-dependent inhibitory effects of Amcp on two human pancreatic cancer cell lines, BxPC-3 and SW1990, in vitro. Cells were treated with Amcp at concentrations of 0.625, 1.25, 2.5, 5, and 10 µM for either 24, 48, or 72 h before the CCK-8 assay.  c  DAPI staining of the cell nucleus. Cells were treated with the indicated compounds for 24 h before fixation and stained with DAPI stain. Fluorescence was observed by using microscopy (Nikon Eclipse Ti). The magnification is ×400. Scale bar = 20 µm.","image_url":"https://www.ebi.ac.uk/europepmc/articles/PMC7470838/bin/41401_2019_354_Fig2_HTML.jpg","paper_title":"A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells.","figure_label":"Fig. 2","figure_number":2,"_schema_version":1,"source_strategy":"pmc_api"},"created_at":"2026-04-21T18:29:40.747630-07:00","updated_at":"2026-04-21T18:29:40.747630-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"external","origin_url":null,"lifecycle_changed_at":"2026-04-21T18:29:40.747630-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"4fd12170-06c1-4a6c-8138-599381714821","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"paper_figures_tool"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[],"incoming_links":[],"current_artifact_id":"paper-fig-paper-8281d7c4ac82-2","is_canonical":true,"supersede_chain":["paper-fig-paper-8281d7c4ac82-2"]}